1 Cationic Antimicrobial Peptide LL - 37 is Effective against both 2 Extra - and Intra - Cellular Staphylococcus aureus
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چکیده
Cationic Antimicrobial Peptide LL-37 is Effective against both 2 Extraand Intra-Cellular Staphylococcus aureus 3 4 5 Running Title: LL-37 effective against extraand intra-cellular S. aureus 6 7 8 9 Jabeen Noore, Adly Noore, and Bingyun Li 10 11 Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, 12 USA 13 Department of Biology, West Virginia University, Morgantown, WV, USA 14 WVNano Initiative, WV, USA 15 Mary Babb Randolph Cancer Center, Morgantown, WV, USA 16 17
منابع مشابه
Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus.
OBJECTIVES The susceptibility of clinical isolates of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), to host-derived cationic antimicrobial peptides was investigated. METHODS We examined the susceptibility of 190 clinical strains of methicillin-susceptible S. aureus (MSSA) and 304 strains of MRSA to two different classes of cationic antimicrobial peptides: LL-37 and ...
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Objectives Staphylococcus aureus small colony variants (SCVs) cause persistent infections and are resistant to cationic antibiotics. Antimicrobial peptides (AMPs) have been suggested as promising alternatives for treating antibiotic-resistant bacteria. We investigated the capacity of the human cationic AMP LL-37 to kill SCVs in the presence of physiological concentrations of bicarbonate, which ...
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Both bacterial and host factors contribute to complicated bloodstream infection (BSI) caused by Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). One bacterial factor that may affect the persistence of S. aureus in complicated BSI is reduced susceptibility to the innate immune defence peptide LL-37. LL-37 susceptibility among S. aureus isolates causing uncomplicated and co...
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Host defense peptides (often called cationic antimicrobial peptides) have pleiotropic immunomodulatory functions. The human host defense peptide LL-37 is up-regulated at sites of infection and has little or no antimicrobial activity in tissue-culture media but under the same conditions, demonstrates immunomodulatory effects on epithelial cells, monocytes, and dendritic cells (DC). These effects...
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BACKGROUND The only human cathelicidin, LL-37, and the innate defense regulator peptide IDR-1, which have been proven to have antimicrobial activity, represent essential elements of immunity. Our previous study showed that the peptide LL-37 was protective in vitro to attenuate LTA-induced inflammatory effects. Methicillin-resistant staphylococcus aureus (MRSA) causes a multitude of serious and ...
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